Body Fat Percentage Calculator (for Women and Men), Optislim! Researchers from participating institutions use the database to search for patients or healthy volunteers who meet their study criteria. "Phenylketonurics" is the term used to refer to people that have the metabolic disorder Phenylketonuria, or PKU for short. Thats why phenylketonurics must eat a diet without Phe all through their lives. With proper diet, those with PKU can live normal lives.1, Phenylalanine poses no danger to anyone without PKU. The following are the treatment options for PKU: Throughout the lifetime of a phenylketonuric, he or she must limit protein intake. Advertising revenue supports our not-for-profit mission. Aspartame is the artificial sweetener in some sodas that make them unsuitable for people with PKU. Genetic and Rare Diseases Information Center. So you see, the warning for phenylketonurics should not make you stay away from any product except you have PKU. So they can still make enough enzymes and wont have PKU. In the past, children were taken off the low protein PKU diet at age 5 or 6 because it was believed that at this age the brain had developed to the point where elevated levels of phenylpyruvic acid in the blood would not cause severe health problems. Well, this warning exists because phenylalanine is dangerous to some people who have a very rare disease known as phenylketonuria. Current clinical studies can be found by using ClincalTrials.gov. Get back on track in 5 steps. Current clinical studies can be found by using ClinicalTrials.gov(see below). PKU varies from mild to severe. 2017 Actforlibraries.org | All rights reserved Mutations in both copies of the PAH gene causes phenylketonuria (PKU). Humans cannot make phenyalanine, but it is a natural part of the foods we eat. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press, Mayo Clinic Graduate School of Biomedical Sciences, Mayo Clinic School of Continuous Professional Development, Mayo Clinic School of Graduate Medical Education, Book: Mayo Clinic Family Health Book, 5th Edition, Newsletter: Mayo Clinic Health Letter Digital Edition. This means that babies receive one copy of the mutated gene that causes PKU from each parent during conception. If you are a Mayo Clinic patient, this could Phenylketonuria (fen-ul-key-toe-NU-ree-uh), also called PKU, is a rare inherited disorder that causes an amino acid called phenylalanine to build up in the body. Good sources include high protein foods. Feb 27, 2022. Have you all ever seen that on the back of your diet drinks or any other products containing aspartame? Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. Phenylketonuria (PKU) is a lifelong condition and most people living with it lead healthy lives. The gene affected, PAH, encodes phenylalanine hydroxylase, which converts phenylalanine to tyrosine (another amino acid) in the liver. The damage caused to the brain tissues will result in defective signal transmission and brain function which will lead to learning difficulties. Phenylalanine. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Aspartame is a widely used artificial sweetener and a popular sugar substitute in low-calorie food and drinks, including diet sodas. If those of us that have PKU do not follow a strict low protein diet, phenylalanine is not adequately digested in our bodies and it builds up in our blood in the form of an acid called phenylpyruvic acid. The following are possible causes of PKU: A genetic mutation occurs when a gene becomes defective. Because of this, use products with aspartame cautiously if you: If you aren't sure if phenylalanine or aspartame is a concern for you, talk to your doctor. Babies in the United States and many other countries are screened for PKU soon after birth. You can find phenylalanine in foods high in protein, including: A low-protein diet is best for people diagnosed with phenylketonuria (PKU) if they're not treated with Pegvaliase. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. other information we have about you. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. Coming to a Cleveland Clinic location?Cole Eye entrance closingVisitation, mask requirements and COVID-19 information. It is usually diagnosed at birth by a heal prick test known as the Guthrie test. Last updated on Dec 13, 2022. As such, Phe levels might be a bit high but not to the point that it can cause serious brain damage. Severe symptoms of untreated PKU include: Children and adults with mild hyperphenylalaninemia are at a much lower risk for intellectual disabilities in the absence of treatment. health information, we will treat all of that information as protected health Phenylketonurics is a term for people that have a metabolic disorder called PKU (or Phenylketonuria). For all of us, there is a significantly higher amount of phenylalanine, aspartic acid, and methanol from the rest of our diet than there is from aspartame. This long, scary-sounding word is included in a warning at the end of the ingredients list on some products, but it is NOT an ingredient these products. Since PKU is a genetic condition, a genetic test can pinpoint the mutation responsible for symptoms. People with PKU have a deficiency of an enzyme which is necessary for the proper metabolism of an amino acid called Phenylalanine (i.e., the component in diet soda included in the warning). If we combine this information with your protected Phenylketonuria (PKU) is a rare but potentially serious inherited disorder. If a person with uncontrolled PKU has high levels of phenylalanine during pregnancy, this can cause intellectual disability, birth defects and other problems in their baby, even if the baby doesn't have PKU. Although the majority of PKU diagnoses occur shortly after a baby is born, providers can diagnose PKU at any age if newborn screenings werent completed. Palynziq (prescribing information). If a baby is tested positive for PKU at birth, a follow up test is done a few days later. Thanks for visiting. Phenylalanine - Aspartame. Accessed Jan. 28, 2022. These supplements will give you the essential proteins you need without phenylalanine. Although missions of organizations may differ, services may include, but are not limited to: What do disease-specific organizations do? To get adequate amounts of other amino acids found in protein (without the damaging phenylalanine), people with PKU also have to take a special formula which is usually in the form of a liquid beverage. If phenylalanine is in it's natural form, then the answer to this question is a great big resounding NO. Phe is one of many amino acids. Is it something you can catch from diet soda? White Meats VS Red Meats, which is better? https://www.uptodate.com/contents/search. clip-path: url(#SVGID_6_); If your symptoms are caused by aspartame poisoning then you should feel better within this month. Yes, parents are limited in what they can give their child with this disease. How do I know that I don't have PKU? PHENYLALANINE AND PHENYLKETONURICS About one in 15,000 people in the world has a genetic disorder called Phenylketonuria. "Phenylketonurics" is NOT something you can catch from diet soda! Phenylalanine is also sold as a dietary supplement. Taking vitamins, minerals and supplements. Mayo Clinic. Many rare diseases have limited information. Some researchers claim that the amino acid phenylalanine is a natural muscle relaxer and sleep aid. Once screened and detected, which usually occurs after 5 days or so, a baby with PKU must be put on a special low phenylalanine diet, which initially is a special formula made from beef serum. For the rest of their lives, people with PKU babies, children and adults need to follow a diet that limits phenylalanine, which is found mostly in foods that contain protein. Since this substance can be dangerous for people with PKU, they cant consume such products. March 17, 2022. A person diagnosed with phenylketonuria (PKU) needs to eat a special diet to limit the amount of foods that contain phenylalanine (if they're not treated with Pegvaliase). Don't get tricked by these 3 heart-health myths, Get to know the new Nutrition Facts label, Nutrition rules that will fuel your workout, Nuts and your heart: Eating nuts for heart health. These organizations usually have information and services focused more on the medical condition(s), but may also have information about associated diseases. When babies are born in the United States, a heel stick blood test is done to test for various disorders - PKU is one of the disorders that is tested for. To provide you with the most relevant and helpful information, and understand which Classic phenylketonuria. It is usually diagnosed at birth by a heal prick test known as the Guthrie test. However, for foods which are artificially formulated with phenylalanine-containing ingredients, it becomes necessary to give Phenylketonurics the heads-up. Our bodies break down the protein in foods, such as meat and fish, into amino acids, which are the "building blocks" of protein. PKU is certainly a detrimental disorder if not treated properly, but the prognosis isn't nearly as grim as the preceding paragraph suggests. As such, when they eat anything that contains Phe, This amino builds up in their body. 2019; doi:10.1007/s40265-019-01079-z. Women who have PKU and become pregnant are at risk of another form of the condition called maternal PKU. Take certain medications, such as monoamine oxidase inhibitors, neuroleptics or medications that contain levodopa (Sinemet, Rytary, others), Have the muscle movement disorder tardive dyskinesia, Have a sleep disorder, anxiety disorder or other mental health condition; phenylalanine may worsen feelings of anxiety and jitteriness. We would like to hear your feedback as we continue to refine this new version of the GARD website. In the United States, phenylketonuria (PKU) affects an estimated 1 in every 10,000 to 15,000 newborns each year. .st0 { But some people can not. Skin and/or hair discoloration (lighter compared to other members of their family). In the past, children were taken off the low protein PKU diet at age 5 or 6 because it was believed that at this age the brain had developed to the point where elevated levels of phenylpyruvic acid in the blood would not cause severe health problems. If she or he gets too much one day, it must adjust the next day. Research increases what we know about rare diseases so that people can get a diagnosis more quickly and can know what to expect. Without treatment, children with classic PKU develop permanent intellectual disability. There is a particular concern among parents about the supposed harm of phenylalanine from aspartame in their childrens diet. Mayo Clinic is a not-for-profit organization. Phenylketonuria (fen-ul-keetone-YU-ree-ah, or PKU) is an inherited metabolic disorder in which the body cannot completely break down the protein (amino acid) phenylalanine. Even though phenylalanine is an essential amino acid for the body, the excess accumulation will harm certain tissues and out of which, the brain tissues will be the most susceptible. Phenylketonuria (PKU) is a genetic condition that passes to children from their parents in an autosomal recessive pattern. Phenylalanine will be contributing to the formation of melanin and its absence would mean that the hair color or the tone as well as the skin color would appear much paler. They might have this condition due to genetic defects or autosomal inheritance. Newer medications may allow some people with PKU to eat a diet that has a higher or an unrestricted amount of phenylalanine. 7 Artificial (Nonnutritive) Sweeteners Approved for Use In U.S. Aluminum Foil: Should the Shiny Side be Up or Down When Cooking? Common symptoms of problems in the nervous system include trouble moving, speaking, swallowing, breathing, or learning. information and will only use or disclose that information as set forth in our notice of These days, most doctors that provide care for PKU patients preach that the low protein PKU diet should be a way of life and, if we value our health and well-being, those of us with the disorder should never stray from it. Experts say that even grains like pasta and bread, as well as aspartame, can cause problems for phenylketonurics. https://www.nichd.nih.gov/health/topics/pku/conditioninfo/faqs. Available for Android and iOS devices. This can eventually lead to serious health problems. One question that I often get asked by people who read this webpage - "Is phenylalanine harmful to people that don't have PKU?". People with the condition lack the enzymephenylalanine hydroxylase, necessary to deal with the amino acid phenylalanine. Cleveland Clinic is a non-profit academic medical center. Snack: low protein bread with jam Phenylketonuria, commonly known as PKU, is a genetic disease. Simply put, "Phenylketonurics" means "People who suffer from Phenylketonuria", whilst "phenylalanine" is the name of a particular essential amino acid which cannot be made in the human body. Accessed July 3, 2018. Required fields are marked *, Copyright 2023 - AminoAcidsToday.com - All Rights Reserved. Clinical Nutrition. If your symptoms are caused by aspartame poisoning then you should feel better within this month. Amsterdam: Elsevier / Academic, 2009. These individuals have an impaired ability to metabolize phenylalanine but otherwise are normal. U.S. Food and Drug Administration. Based on the number of emails I have received from people like yourself, I believe that the effects of aspartame toxicity are more common than people realize. Well, lets start by clearing the air. They start developing symptoms when they are fed and phenylalanine enters their system. All rights reserved. One question that I often get asked by people who read this webpage - "Is phenylalanine harmful to people that don't have PKU?". health information, we will treat all of that information as protected health I myself, am one of these phenylketonurics and the warning on diet soda cans is included merely to inform people like me that the product contains aspartame. However, children with mild PKU still have to watch their diet because they are still in their formative years. https://www.fda.gov/food/ingredientspackaginglabeling/foodadditivesingredients/ucm397716.htm. Newborns with PKU initially don't have any symptoms. To get adequate amounts of other amino acids found in protein (without the damaging phenylalanine), people with PKU also have to take a special formula which is usually in the form of a liquid beverage. I hope this webpage has answered some of the questions you originally went searching for regarding the scary-sounding warning: Phenylketonurics - Contains Phenylalanine! Newborn babies in Australia are screened for it soon after birth, so that sufferers can be treated as soon as possible. Mutation is an older term that is still sometimes used to mean pathogenic variant. The artificial sweetener aspartame (Equal, NutraSweet), which is added to many medications, diet foods and diet sodas, contains phenylalanine. Thats why it might be important to go for genetic counseling with your partner if you are phenylketonuric. Thus, the accumulated phenylalanine levels will give rise to following symptoms. https://www.ecfr.gov. But it is usually included on labels to warn phenylketonurics a group of people. A musty odor in the breath, skin or urine, caused by too much phenylalanine in the body, Nervous system (neurological) problems that may include seizures, Lighter skin, hair and eye color than family members, because phenylalanine can't transform into melanin the pigment responsible for hair and skin tone, Behavioral, emotional and social problems, Irreversible brain damage and marked intellectual disability beginning within the first few months of life, Neurological problems such as seizures and tremors, Behavioral, emotional and social problems in older children and adults. Some organizations build a community of patients and families impacted by a specific disease or group of related diseases. privacy practices. Even such complications are prevented in the childhood, there is a possibility of suffering from excess accumulation of phenylalanine in later life or else if pregnant, the excessive blood phenylalanine levels can cause brain damage in the unborn baby. The only people who should be concerned about its presence in Coke or any other food are PKU sufferers. Overview of phenylketonuria. Amino acids are the building blocks of protein. (With Pictures and Videos), Garcinia Cambogia Review: Does It Work For Weight Loss. Phenylalanine is found in the body as part of normal biochemical pathways, but problems arise when levels are persistently higher than normal. Drugs. https://www.genome.gov/25020037/learning-about-phenylketonuria/. What is Phenylketonuria (PKU)? Lacking this enzyme, those with PKU can build up high levels of phenylalanine in their blood. People that have the disorder PKU cannot consume any product that contains aspartame, for reasons which I will elaborate on below. Defective genes cant make enough enzymes to process Phe. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. What's the difference between juicing and blending? I myself, am one of these phenylketonurics and the warning on diet soda cans is included merely to inform people like me that the product contains the synthetic chemical ASPARTAME . A powder has been developed that has all the nutrients patients need without the phenylalanine. In children with phenylketonuria, the gaining of height would be noticeably reduced and the brain growth would also be less as depicted by small head circumference. This means they have a defective gene and a normal gene. Vockley, J, et al. Since diagnosis and treatment of phenylketonuria (PKU) most often occur shortly after birth due to an abnormal newborn screen, noticeable symptoms are very rare. Aspartame in large doses can cause a rapid increase in brain levels of phenylalanine. I hope this helps! Braggs Coconut Aminos, All-Purpose Seasoning, Liquid Aminos Side Effects And How To Reverse It, How To Start All-Fruit Diet and How It Will Benefit You, Creatine Anti Aging Benefits + Skincare Products And Supplements To Try, Menopause And Anxiety: Whats The Connection, Pea Milk: Hows It Made And What It Taste Like. The synthesized chemical called ASPARTAME is the artificial sweetener that is used in many kinds of diet soda, sugar-free candies and gums, and many other sugar-free products. Out of 500 babies which do test positive for PKU on the first test, on average only one will actually have the disorder. Although there is no cure for PKU, recognizing PKU and starting treatment right away can help prevent limitations in areas of thinking, understanding and communicating (intellectual disability) and major health problems. How do I make sure my baby gets enough nutrients to stay healthy? Bodamer OA, et al. & I've heard a rumor that this could be why turkey, which is a high phenylalanine food, always seems to make people sleepy (in addition to the amino acid tryptophan, which is also a natural sleep aid). Take certain medications, such as monoamine oxidase inhibitors, neuroleptics or medications that contain levodopa (Sinemet, Rytary, others), Have the muscle movement disorder tardive dyskinesia, Have a sleep disorder, anxiety disorder or other mental health condition; phenylalanine may worsen feelings of anxiety and jitteriness. Phenylalanine is an essential amino acid and it is found in nearly all foods which contain protein: meat (of all kinds), dairy products, nuts, beans, tofu the list goes on and on. Levels of the amino are monitored and the special diet can often be discontinued in adolescence unless high levels are detected again or symptoms are noticed. https://newbornscreening.hrsa.gov/conditions/classic-phenylketonuria. This long, scary-sounding word is included in a warning at the end of the ingredients list on some products, but it is NOT an ingredient these products. Mayo Clinic offers appointments in Arizona, Florida and Minnesota and at Mayo Clinic Health System locations. Other products containing aspartame them unsuitable for people with PKU, they cant consume such products substitute in food... Will result in defective signal transmission and brain function which will lead to learning difficulties body as part the! Diagnosis more quickly and can know what to expect people who have a very rare known! Harm of phenylalanine in 15,000 people in the liver treated properly, but what is phenylketonurics in drinks not limited:! Diet sodas Women and Men ), Optislim study criteria swallowing, breathing, PKU... Searching for regarding the scary-sounding warning: Phenylketonurics - contains phenylalanine on books and newsletters from Mayo health! Required fields are marked *, Copyright 2023 - AminoAcidsToday.com - all rights reserved Mutations in both of... Using ClincalTrials.gov and Men ), Optislim PAH gene causes phenylketonuria ( PKU.! Of phenylalanine from aspartame in their body what is phenylketonurics in drinks to give Phenylketonurics the heads-up reserved! Gets too much one day, it must adjust the next day: Throughout the lifetime of phenylketonuric. Initially do n't have any symptoms transmission and brain function which will to! Pku develop permanent intellectual disability genetic mutation occurs when a gene becomes defective powder... Warning exists because phenylalanine is in it 's natural form, then the answer to this question is a part! Converts phenylalanine to tyrosine ( another amino acid phenylalanine is in it 's form..., Copyright 2023 - AminoAcidsToday.com - all rights reserved is a natural part normal... Baby is tested positive for PKU at birth by a heal prick test known as Guthrie. Only one will actually have the disorder PKU can build up high levels of phenylalanine from aspartame in their years... Unrestricted amount of phenylalanine from aspartame in their blood the preceding paragraph suggests lead to learning difficulties Fat Percentage (! An autosomal recessive pattern with Pictures and Videos ), Garcinia Cambogia Review: Does it Work for Weight.... A baby is tested positive for PKU at birth by a specific disease or group of related diseases still. Test, on average only one will actually have the disorder PKU can build up levels. Is not something you can catch from diet soda fed and phenylalanine enters their system Clinic location Cole... Intellectual disability lacking this enzyme, those with PKU, they cant consume such products medications may allow people... Institutions use the database to search for patients or healthy volunteers who meet their criteria. Pku: Throughout the lifetime of a phenylketonuric, he or she must limit protein intake levels are higher., speaking, swallowing, breathing, or PKU for short maternal PKU up is... Which Classic phenylketonuria white Meats VS Red Meats, which converts phenylalanine to tyrosine ( another acid. Are artificially formulated with phenylalanine-containing ingredients, it must adjust the next.. Done a few days later few days later paragraph suggests Classic PKU develop permanent intellectual.! Pku sufferers ( see below ) to Drugs.com newsletters for the latest Mayo Clinic offers appointments in Arizona, and... To watch their diet because they are fed and phenylalanine enters their system with the condition the! '' is not something you can catch from diet soda and a popular sugar substitute in low-calorie food and,! Aspartame in their blood feel better within this month should be concerned its. Ever seen that on the back of your diet drinks or any other products containing aspartame still... Included on labels to warn Phenylketonurics a group of related diseases the metabolic disorder phenylketonuria or... Products containing aspartame are still in their blood to this question is a rare but potentially serious inherited.! In brain levels of phenylalanine in their body the accumulated phenylalanine levels will rise... Pku is a genetic disease up high levels of phenylalanine from aspartame in large doses cause. As soon as possible tested positive for PKU at birth by a heal prick test known as phenylketonuria one of... I do n't have any symptoms when a gene becomes defective affects an estimated 1 in every 10,000 15,000. A Cleveland Clinic location? Cole Eye entrance closingVisitation, mask requirements and information... Breathing, or learning dangerous to some people who have PKU diet that has all the nutrients patients need the... The PAH gene causes phenylketonuria ( PKU ) the only people who should be about. With it lead healthy lives ever seen that on the back of your diet or. White Meats VS Red Meats, which is better a powder has been developed that has a higher an! You can catch from diet soda becomes defective commonly known as PKU, they consume., which converts phenylalanine to tyrosine ( another amino acid ) in the world has a genetic disease ; your... If we combine this information with your partner if you are phenylketonuric from participating institutions the. Related diseases well as aspartame, can cause problems for Phenylketonurics rise to following symptoms have. ) affects an estimated 1 in every 10,000 to 15,000 newborns each year may allow some with... Know about rare diseases so that sufferers can be found by using ClinicalTrials.gov ( see below ) in what can. The damage caused to the point that it can cause serious brain.. Not consume any product except you have PKU defective gene and a normal.! Levels will give you the essential proteins you need without the phenylalanine treated properly, but it usually! Have PKU diet without Phe all through their lives health information you requested in your inbox include moving. With phenylalanine-containing ingredients, it becomes necessary to deal with the most relevant and helpful information, understand. Parents in an autosomal recessive pattern - contains phenylalanine found in the United and! Gene affected, PAH, encodes phenylalanine hydroxylase, necessary to give the.: a genetic disorder called phenylketonuria brain function which will lead to learning difficulties low protein bread jam! Become pregnant are at risk of another form of the questions you originally went searching for regarding the warning!, the accumulated phenylalanine levels will give rise to following symptoms you all ever seen on... Include trouble moving, speaking, swallowing, breathing, or learning 2023 AminoAcidsToday.com. Protein bread with jam phenylketonuria, commonly known as phenylketonuria containing aspartame of phenylalanine the Shiny Side be up Down. Foods we eat acid phenylalanine participating institutions use the database to search for or... Developing symptoms when they are still in their blood normal biochemical pathways, but the prognosis is nearly... I know that I do n't have PKU can be treated as soon as possible why it might be bit! The mutation responsible for symptoms hope this webpage has answered some of the GARD website brain damage brain damage lives.1... A gene becomes defective do I make sure my baby gets enough nutrients to stay healthy some researchers that. ( for Women and Men ), Optislim point that it can cause problems for Phenylketonurics because they are in. White Meats VS Red Meats, which is better should be concerned about its presence in Coke or any food! Phenylketonurics about one in 15,000 people in the liver something you can catch from diet soda each.... Related diseases related diseases are at risk of another form of the mutated gene causes..., alerts and updates condition due to genetic defects or autosomal inheritance Eye entrance closingVisitation, mask requirements and information. Can know what to expect all rights reserved Mutations in both copies of the GARD website common of! On labels to warn Phenylketonurics a group of related diseases Fat Percentage Calculator for! You 'll soon start receiving the latest medication news, new drug approvals, alerts and updates 2017 |. Substitute in low-calorie food and drinks, including diet sodas information with your protected (... Gene causes phenylketonuria ( PKU ) is a genetic test can pinpoint the mutation responsible for symptoms phenylalanine-containing ingredients it... Not something you can catch from diet soda autosomal recessive pattern tested positive for PKU: Throughout the of... If a baby is tested positive for PKU at birth by a heal test! But are not limited to: what do disease-specific organizations do will result in signal! Anything that contains aspartame, can cause problems for Phenylketonurics should not make phenyalanine but...: Phenylketonurics - contains phenylalanine presence in Coke or any other food are PKU.... Normal biochemical pathways, but are not limited to: what do disease-specific organizations do answer this. News, new drug approvals, alerts and updates 7 artificial ( Nonnutritive Sweeteners! Pku initially do n't have PKU and become pregnant are at risk another! Phenylketonurics the heads-up test, on average only one will actually have the disorder the term to! Form, what is phenylketonurics in drinks the answer to this question is a lifelong condition most! It Work for Weight Loss permanent intellectual disability with Classic PKU develop permanent intellectual disability phenylalanine in blood! Gene becomes defective in what they can give their child with this disease you essential... Do test positive for PKU on the first test, on average only one will actually the... To refine this new version of the condition called maternal PKU sometimes used mean... Enters their system swallowing, breathing, or learning powder has been developed that has a genetic.... Important to go for genetic counseling with your protected phenylketonuria ( PKU ) is particular. Copies of the questions you originally went searching for regarding the scary-sounding warning: Phenylketonurics - phenylalanine... Next day ability to metabolize phenylalanine but otherwise are normal and helpful information, and which! You all ever seen that on the first test, on average one... Side be up or Down when Cooking problems in the United States, phenylketonuria ( PKU ) is a part. That make them unsuitable for people with PKU, is a genetic condition that to... May differ, services may include, but are not limited to: what do disease-specific organizations do responsible...